Aim: Diabetic nephropathy (DN), classically defined by the presence of proteinuria is one of the major late microvascular
complications of type 1 and type 2 diabetes mellitus and leading to a decline in renal function. The present study is aimed to
understand the potential modifier effect of PPARG gene on the advancement of chronic kidney disease in DN.
Methods: A total of 187 DN patients (101 male and 86 female) with persistent urine albuminuria (>300 mg/L) were included
in the study. The KASPar SNP genotyping method (KBioscience, Herts., UK) was adopted for genotyping three PPARG gene
polymorphisms (rs10865710: -681C>G; rs1801282: Pro12Ala; rs3856806: 1431C>T). The interaction between PPARG genotypes
and poor glycemic status or hyperlipidemia in chronic kidney disease (CKD) progression was analyzed using Mantel-Haenszel
stratified analysis. We performed a multivariate logistic regression analysis to identify the adjusted effects of risk factors on CKD
progression in DN.
Results: In univariate analysis, the hyperlipidemia, glycemic control, duration of diabetes mellitus and the PPARG polymorphisms
did not show a significant association with the advancement of CKD. In multivariate analysis, none of the SNPs of PPARG showed
significant association with CKD risk. No confounding effect of PPARG genotypes was observed.
Conclusions: Our results suggest that PPARG gene is not a major risk factor for susceptibility to the progression of CKD in South
Indian DN patients