ISSN: 2423-6438  
J Renal Endocrinol. 2018;4(1):12-12.

Hypothesis

PPARG genotypes are not a major modifiers of chronic kidney disease progression among the diabetic nephropathy patients

Mookambika R. Velayuthan 1,2, Ramprasad Elumalai 1, Bhaskar V.K.S. Lakkakula 1, Soundararajan Periyasamy 1,4 *

1 Department of Nephrology, Sri Ramachandra University, Chennai, India.
2 Department of Medicine, Mookambika Institute of Medical Sciences, Kulasekaram, Tamil Nadu, India.
3 Sickle Cell Institute Chhattisgarh, Raipur, India.
4 Department of Nephrology, Saveetha Medical College, Saveetha Nagar, Thandalam, Chennai, India
*Corresponding Author: Soundararajan Periyasamy, Email: Email: srajan_51@hotmail.com

Abstract

Aim: Diabetic nephropathy (DN), classically defined by the presence of proteinuria is one of the major late microvascular complications of type 1 and type 2 diabetes mellitus and leading to a decline in renal function. The present study is aimed to understand the potential modifier effect of PPARG gene on the advancement of chronic kidney disease in DN.

Methods: A total of 187 DN patients (101 male and 86 female) with persistent urine albuminuria (>300 mg/L) were included in the study. The KASPar SNP genotyping method (KBioscience, Herts., UK) was adopted for genotyping three PPARG gene polymorphisms (rs10865710: -681C>G; rs1801282: Pro12Ala; rs3856806: 1431C>T). The interaction between PPARG genotypes and poor glycemic status or hyperlipidemia in chronic kidney disease (CKD) progression was analyzed using Mantel-Haenszel stratified analysis. We performed a multivariate logistic regression analysis to identify the adjusted effects of risk factors on CKD progression in DN.

Results: In univariate analysis, the hyperlipidemia, glycemic control, duration of diabetes mellitus and the PPARG polymorphisms did not show a significant association with the advancement of CKD. In multivariate analysis, none of the SNPs of PPARG showed significant association with CKD risk. No confounding effect of PPARG genotypes was observed.

Conclusions: Our results suggest that PPARG gene is not a major risk factor for susceptibility to the progression of CKD in South Indian DN patients

Implication for health policy/practice/research/ medical education

PPAR agonists are potential renoprotective therapeutic agents that would prevent the development or the progression of diabetic nephropathy. This study helps in identifying the exact role of PPARG polymorphism to predict the progression of chronic kidney disease in diabetic nephropathy.

Citation: Velayuthan MR, Elumalai R, Lakkakula BVKS, Periyasamy S. PPARG genotypes are not a major modifiers of chronic kidney disease progression among the diabetic nephropathy patients. J Renal Endocrinol. 2018;4:e12. DOI:10.15171/jre.2018.12.

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Submitted: 02 Nov 2017

Accepted: 20 Dec 2017
First published online: 08 Jan 2018
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