Nanotechnology is widely used at present. The effect of nanoparticle on health aspect is an important consideration. Whereas
the nanoparticle is proven useful in clinical aspect, the negative effect should be mentioned. The interference of nanoparticle on
clinical laboratory investigation is an important issue. Here, the authors assess the effect of gold nanoparticle contamination in
urine amphetamine test. According to the study, the interference can be seen. The false positive of the test due to the contamination
is observed. The effect of nanoparticle on the clinical forensic laboratory test is the new issue to be considered at present.