Fructose intake is advised to regulate serum glucose concentration and diabetes. However, high intake of fructose has been shown to be associated with the outbreak of obesity, diabetes mellitus, hypertriglyceridemia and also non-alcoholic fatty liver disease. Furthermore, it seems to elevate the risk of gout and hence kidney stones. In this regard, the mechanism of fructose on the induction of chronic kidney disease is ascribed to its role in hypertension and diabetes. With respect to the contradictory reports of fructose intake on diabetes, the aim of this review is to explain this inconsistence and its effect on induction of renal disease.