ISSN: 2423-6438  
J Renal Endocrinol. 2017;3(1): e5.
doi:10.15171/jre.2017.05

Original Article

Association of serum adiponectin levels with pulmonary artery pressure in maintenance hemodialysis patients

Mohammad Reza Tamadon 1, Maryam Heidari 2, Saeed Mardani 2 *

1 Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran.
2 Department of Internal Medicine, Division of Nephrology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
*Corresponding Author: Saeed Mardani, Email: dr_s_mardani@yahoo.com

Abstract

Introduction: Abnormal pulmonary artery pressure (PAP) in hemodialysis patients is associated with significant increase in morbidity and mortality.

Objectives: Considering the significance of pulmonary hypertension in hemodialysis patients, a study was designed to assess the association of serum adiponectin levels and PAP in a group of stable hemodialysis patients.

Patients and Methods: The study was conducted on a group of non-diabetic hemodialysis patients. The study was carried out in hemodialysis ward of Shahrekord University of Medical Sciences for a period of 4 months in 2013. The studied patients had a history of dialysis from 1 to 22 years.

Results: In our study, out of 76 hemodialysis patients, 46.1% were female and 53.9% were male. The mean PAP in female hemodialysis patients was 29.74 mm Hg, which was about 9% less than the PAP observed in male hemodialysis patients. Mean adiponectin levels in all the patients, males, and females, respectively, was 10.59, 10.42, and 10.80 μg/mL respectively. In this study a significant and positive relationship between adiponectin levels and PAP in female hemodialysis patients (r = 0.35, P = 0.04) was detected.

Conclusion: This association requires more investigation on the significant role of adiponectin in hemodialysis patients.

Citation: Tamadon MR, Heidari Mm Mardani S. Association of serum adiponectin levels with pulmonary artery pressure in maintenance hemodialysis patients . J Renal Endocrinol. 2017;3:e05. DOI: 10.15171/jre.2017.05.

Implication for health policy/practice/research/medical education

Studies regarding prevalence of pulmonary hypertension and its associated parameters and also its impact on hemodialysis outcomes are limited. In fact, pulmonary hypertension is a disease can be caused by various underlying situations or an intrinsic modification of the pulmonary vasculature. In this study, we found a significant and positive relationship between adiponectin levels and pulmonary artery pressure(PAP) in female non-diabetic hemodialysis patients. This association requires more investigation on the significant role of adiponectin in hemodialysis patients.

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Submitted: 30 Oct 2016

Accepted: 15 Dec 2016
First published online: 08 Jan 2017
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