Submitted: 11 Jun 2020
Accepted: 07 Jul 2020
ePublished: 16 Sep 2020
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J Renal Endocrinol. 2021;7(1): e04.
  Abstract View: 17
  PDF Download: 12

Case Report

Impact of gender, C-reactive protein and body mass index on erythropoietin resistance index in maintenance hemodialysis patients

Asim Osman 1, Nada Awad Alkareem 2, Baha eldin Elawad 3, Ogail Dawod 4, Mohammed Elshiekh 5 *

1 Department of Human Physiology, Faculty of Medicine, University of Gadarif, Gadarif, Sudan.
2 Department of Physiology, Faculty of Medicine, Merowe University of Technology, Merowe, Sudan.
3 Department of Physiology, Faculty of Medicine, University of Umm-Alqura, Holy Makkah, Kingdom of Saudi Arabia.
4 Department of MLT, Faculty of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia.
5 Department of Physiology, Faculty of Medicine and Health Sciences, University of Dongola, Dongola, Sudan.
*Corresponding Author: Mohammed Elshiekh, Email: mishairmo@gmail.com m.a.saeed@uofd.edu.sd,

Abstract

Introduction: Anemia is caused by a variety of mechanisms in chronic kidney disease (CKD), including erythropoietin (EPO) deficiency, resistance to erythropoiesis-stimulating agents (ESAs), impaired iron metabolism and its clinical management remains challenging.

Objectives: The aim of the current study was to evaluate the impact of CRP, BMI, gender and duration of hemodialysis.

Patients and Methods: A total of 94 maintenance HD patients participated in this study. Laboratory investigation included CBC, renal function test and qualitatively C-reactive protein was performed. Erythropoietin resistance index (ERI) was calculated as weekly EPO dose/ body weight in kg/hemoglobin level.

Results: Female gender had significantly higher ERI (11.36 ± 1.52) compared to male HD patients (10.68 ± 1.56) (P ˃ 0.05). Patients with low BMI had significant higher ERI (12.08 ± 1.09) compared to HD patients with overweight (10.62 ± 0.79) and obese (9.62 ± 1.68) (P ˃ 0.05). The highest ERI were found in the positive CPR group (P ˃ 0.05) compared to negative CRP group. There is no significant difference between duration of hemodialysis.

Conclusion: Our data exposed that female gender; low BMI and inflammation (positive CRP) contributed to EPO hyporesponsiveness. In addition, there is no significant difference between lengths on hemodialysis.

Keywords: Hemodialysis, Erythropoietin, Hyporesponsiveness, C-reactive protein, Anemia
Citation: K. Impact of gender, C-reactive protein and body mass index on erythropoietin resistance index in maintenance hemodialysis patients. J Renal Endocrinol. 2021;7:e04.
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