Submitted: 28 Oct 2016
Accepted: 04 Dec 2016
ePublished: 26 Dec 2016
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J Renal Endocrinol. 2017;3(1): e01.
  Abstract View: 1163
  PDF Download: 934

Review

Oxidative stress in chronic kidney disease; an updated review on current concepts

Sara Beigrezaei 1, Hamid Nasri 2 *

1 School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
2 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
*Corresponding Author: Prof. Hamid Nasri; hamidnasri@med.mui.ac.ir

Abstract

Chronic renal failure is associated with enhanced oxidative stress. Oxidative stress has been implicated in various pathological systems that are prevalent in both chronic kidney disease (CKD) and cardiovascular disease, most importantly are inflammation and fibrosis. Chronic inflammation is provoked by oxidative stress and chronic degenerative diseases. The inflammatory cells are source of free radicals in the forms of reactive oxygen (O2) and nitrogen species, while reactive oxygen species (ROS) are considered as the most responsible factor in CKD. ROS are able to be harmful in a variety of functional and structures pathways in cells. Oxidative stress rises free radicals are general product of normal aerobic cellular metabolism. While, O2 is vital for life, imbalanced metabolism and excess ROS generation lead into a range of disorders such as CKD. The purpose of this review is to provide an overview of development of oxidative stress, biomarkers, the involvement of mitochondrial dysfunction and the molecular pathways of oxidative stress in CKD.
Keywords: Oxidative stress, Chronic kidney disease, Chronic inflammation, Free radicals, Reactive oxygen species

Citation: Beigrezaei S, Nasri H. Oxidative stress in chronic kidney disease; an updated review on current concepts. J Renal Endocrinol. 2017;3:e01. DOI: 10.15171/jre.2017.01.

Implication for health policy/practice/research/medical education

Oxidative stress has been implicated in various pathological systems that are prevalent in CKD. Chronic inflammation is provoked by oxidative stress and chronic degenerative diseases. The inflammatory cells are sources of free radicals in the forms of reactive O2 and nitrogen species, although ROS are considered as the most responsible factor in CKD.

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