Logo-jre
Submitted: 04 Feb 2021
Accepted: 23 Mar 2021
ePublished: 16 Apr 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Renal Endocrinol. 2021;7(1): e12.
  Abstract View: 95
  PDF Download: 43

Case Report

What about NSAID and secondary minimal change disease in adult’s people? A case report and review of the literature

Erica E Faure 1 ORCID logo, Jorge H. Mukdsi 1 * ORCID logo

1 Universidad Nacional de Córdoba, Facultad de Ciencias Médica, Centro de Microscopía Electrónica, Córdoba, Argentina.
*Corresponding Author: Jorge Mukdsi; Email: mukdsijorge@gmail.com, jorge.mukdsi@unc.edu.ar

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) have been used in the management of inflammatory disease for decades. The spectrum of nephrotoxicity attributed to NSAIDs includes mainly acute tubulointerstitial nephritis. However, much less attention has been given to drug-induced glomerular injury. NSAIDs treating patients presenting with nephrotic syndrome may have a variety of glomerular changes indistinguishable from those found in idiopathic minimal change disease (MCD), for example. The clinical presentation is typically abrupt with nephrotic syndrome while in the elderly it can present as acute renal failure from the beginning. We present an MCD-NSAID induced in elderly patient and discuss possible pathogenic mechanism, thinking about on the indiscriminate use of NSAIDs. Here we report the case of a 66-year-old woman with a history of nephrotic syndrome and hypertension without an apparent secondary etiology. However, an exhaustive history showed and indiscriminate use of NSAIDs. Renal biopsy showed a MCD with a mild interstitial nephritis. To our knowledge the morphology of drug-induced diseases often does not differ from the primary forms, making the distinction difficult. There are subtle clues, although the dialogue between clinician and pathologist is essential to reach an etiological diagnosis. Physicians should suspect glomerulonephritis in patients who receive drugs and its management must be determined based on the histological characteristics of the disease. Although corticosteroid therapy seems to be of value, the effectiveness of this approach must still be tested in randomized and multicentric clinical trials.
Keywords: Non-steroidal anti-inflammatory drugs, Minimal change disease, Adult
Citation: Faure EE, Mukdsi JH. What about NSAID and secondary minimal change disease in adult’s people? A case report and review of the literature. J Renal Endocrinol. 2021;7:e12.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 95

Your browser does not support the canvas element.


PDF Download: 43

Your browser does not support the canvas element.