The novel coronavirus outbreak has become a global health emergency. The common symptoms of COVID-19 disease which have affected a large population are common cold, fatigue, headache and fever. However, complications such as multiple organ failure, acute respiratory syndrome and septic shock are seen in about 5% of patients with persisting severe symptoms and post-COVID syndrome. The COVID-19 acute kidney injury in patients displays damage in the kidney, proteinuria, hematuria and elevated serum creatinine. The symptoms of acute kidney injury vary from mild to severe, which necessitates proper clinical management and renal replacement therapy (RRT). Therefore, it is necessary to understand the pathophysiology of acute kidney injury involving infiltrated immune cells, thrombosis, and cytokine regulation. There is no definite treatment for acute kidney injury; the strategy for preventing the complications will only come through clinical experience. Therefore, more studies are needed for the proper understanding of the disease etiology in acute kidney injury patients with COVID-19. New strategies, International collaboration and multi-disciplinary research are needed to be implemented for the proper management.