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Submitted: 03 Mar 2022
Accepted: 23 Jun 2022
ePublished: 05 Jul 2022
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J Renal Endocrinol. 2022;8: e16061.
doi: 10.34172/jre.2022.16061
  Abstract View: 189
  PDF Download: 98

Review

Genetics association of renin-angiotensin system with atherosclerosis

Negar Nouryazdan 1 ORCID logo, Mohammad Yazdi 1,2 ORCID logo, Asma Alekasir 2 ORCID logo, Samaneh Pakravan 1* ORCID logo

1 Department of Clinical Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
2 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
*Corresponding Author: Corresponding Author: Samaneh Pakravan, Email: , Email: pakravansam3642@gmail.com

Abstract

Angiotensin-converting enzyme (ACE) gene encodes ACE, an enzyme of the renin-angiotensin system (RAS) that plays a significant role in homeostasis and control of blood pressure. It seems that genetic variations can affect ACE function and cause atherosclerosis, one of the most common diseases worldwide, especially in developed countries and one of the leading causes of death in these countries. The presence of ACE insertion/deletion (I/D) affect the function of ACE. This polymorphism can lead to progression of atherosclerosis in some population. Directory of Open Access Journals (DOAJ), Google Scholar and PubMed of the most common diseases worldwide. Additionally, EBSCO and Web of Science have been searched. In this review, we studied the effects of ACE I/D polymorphism in various populations and its influence on the risk of onset and progression of atherosclerosis. Depending on the population and the area under study, polymorphisms can contribute to the risk of disease.

Citation: Nouryazdan N, Yazdi M, Alekasir A, Pakravan S. Genetics association of renin-angiotensin system with atherosclerosis. J Renal Endocrinol. 2022;8:e16061. doi: 10.34172/jre.2022.16061.
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