Submitted: 29 Sep 2022
Accepted: 28 Nov 2022
ePublished: 20 Dec 2022
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J Ren Endocrinol. 2022;8: e25064.
doi: 10.34172/jre.2022.25064
  Abstract View: 148
  PDF Download: 67


Effects of gender on the efficacy and response to COVID-19 vaccination; a review study on current knowledge

Ali Rastegar Kashkouli 1* ORCID logo, Mohsen Jafari 1 ORCID logo, Pourya Yousefi 1 ORCID logo

1 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
*Corresponding Author: Corresponding Author: Ali Rastegar Kashkouli, Email: , Email: dralirastegar97@gmail.com


Vaccination is one of the most important public health strategies to reduce mortality and morbidity of various infectious diseases. The COVID-19 pandemic was declared, on March 11, 2020, since then, the virus has spread rapidly, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have played the main substantial role in advancing the management of the COVID-19 pandemic. As is well known, sex/gender-related differences affect vaccine efficacy, response, and acceptability. This review aims to compare the effects of sexual dimorphism and gender-related differences factors on the efficacy, responses, and acceptance of the COVID-19 vaccines. As far as the COVID-19 vaccine effectiveness is concerned, both males and females with the COVID-19 vaccine showed consistent and impressive efficacy; although males showed slightly greater efficacy, there was no significant correlation between the efficacy of the COVID-19 vaccine and their sex or gender differences. Consequently, to reduce adverse reactions in females, sex differences should be considered in the design of the COVID-19 vaccine. It is also essential to conduct pragmatic trials to verify whether sex differences in vaccine response and efficacy vary with age.

Citation: Rastegar Kashkouli A, Jafari M, Yousefi P. Effects of gender on the efficacy and response to COVID-19 vaccination; a review study on current knowledge. J Ren Endocrinol. 2022;8:e25064. doi: 10.34172/jre.2022.25064.
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