Harini Ravi
1 
, Soumik Das
1 , Ramprasad Elumalai
2 , Gnanasambandan Ramanathan
1* 1 School of BioSciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India.
2 Department of Nephrology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai-600116, India.
Abstract
Obesity is a leading global disease and a major risk factor for diabetes which in turn causes metabolic diseases like chronic kidney disease (CKD) with increased mortality and morbidity. However, the relationship between obesity and diabetic kidney diseases (DKDs) remains unclear. Numerous factors in obesity lead to insulin resistance through adipocyte dysfunction. Insulin resistance is a major player in developing diabetes and promoting kidney disease. Major inflammatory cytokines and adipokines produced by adipocytes in the obese phase have various metabolic effects on the system leading to metabolic diseases. Even though obesity, diabetes, and kidney disease have a well-known correlation, the progression of DKD induced by obesity remains still unclear. In this review, we tried to understand the major pathophysiological mechanism linking obesity and DKDs. In addition, we also try to discuss the clinical manifestations and various effective therapeutics for future treatment.