Submitted: 13 Apr 2023
Accepted: 14 Jun 2023
ePublished: 14 Jun 2023
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J Ren Endocrinol. 2023;9: e25097.
doi: 10.34172/jre.2023.25097
  Abstract View: 78
  PDF Download: 41


Renal effects of hydatiform mole and choriocarcinoma

Hamid Nasri* ORCID logo

1 Nickan Research Institute, Isfahan, Iran
*Corresponding Author: Hamid Nasri, Email: hamidnasri@med.mui.ac.ir,, Email: hamidnasri@yahoo.com


Molar pregnancy is an abnormal growth of trophoblastic tissue in the uterus. It can be either complete or partial. In complete moles, the development of the fetus is absent, while partial moles contain an abnormal gestational sac. Choriocarcinoma is a malignant form that arise from molar tissue. Hydatiform mole and choriocarcinoma are rare and complicated diseases with numerous pathological conditions that can lead to significant kidney damage. Proteinuria, nephrotic syndrome, preeclampsia, decreased glomerular filtration rate, interstitial inflammation, crescentic glomerulonephritis, and thrombosis of the renal veins are the commonly encountered renal disorders with these diseases. Early intervention and treatment during pregnancy minimize these risks and lessen the risk of chronic kidney disease or end-stage renal failure. A multidisciplinary team approach involving obstetricians, nephrologists, pathologists, gynecologists, and radiologists is necessary for optimal management.
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