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Submitted: 18 Nov 2023
Accepted: 05 Jan 2024
ePublished: 13 Jan 2024
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J Ren Endocrinol. 2024;10: e25143.
doi: 10.34172/jre.2024.25143
  Abstract View: 523
  PDF Download: 827

News and Views

New hopes on “SLU-PP-332” as an effective agent for weight loss with indirect kidney protection efficacy; a nephrology point of view

Hamid Nasri* ORCID logo

1 Nickan Research Institute, Isfahan, Iran
*Corresponding Author: Hamid Nasri, Email: nrc@nickanrescorp.com, , Email: hamidnasri@yahoo.com

Abstract

SLU-PP-332 activates estrogen receptor-related orphan receptors, increasing energy expenditure, fatty acid oxidation, and decreasing fat mass accumulation. The drug enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, increases the expression of an estrogen receptor-related orphan receptor target gene, and enhances mitochondrial respiration in C2C12 myocytes. The drug also increases oxidative fibers in skeletal muscle and improves exercise endurance in C57BL/6J mice.

Citation: Nasri H. New hopes on “SLU-PP-332” as an effective agent for weight loss with indirect kidney protection efficacy; a nephrology point of view. J Ren Endocrinol. 2024;10:e25143. doi: 10.34172/jre.2024.25143.
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