Renal morphologic lesions in disseminated intravascular coagulation; a letter to the editor on recent findings

Abstract

Disseminated intravascular coagulation (DIC)-associated renal lesions may resemble those seen in thrombotic microangiopathy, which includes conditions like hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura. Thrombotic microangiopathy is characterized by widespread microthrombi formation in small blood vessels, leading to organ damage, including the kidneys. Bleeding tendencies in DIC can manifest in the renal interstitium, leading to hemorrhage and edema within the kidney tissue. DIC can also cause damage to the renal tubules, impairing their ability to reabsorb electrolytes and maintain fluid balance. This can result in electrolyte imbalances and further exacerbate kidney dysfunction. In severe cases, DIC can cause renal infarction.

Keywords: Disseminated intravascular coagulation, Microthrombi, Microangiopathic hemolysis, Hemolytic-uremic syndrome