Aggravation of hypertension by gut microbiota dysbiosis; a short-review on new concepts

Abstract

Gut microbiota dysbiosis, characterized by reduced diversity and richness, as well as an imbalance in specific bacterial taxa, is closely associated with hypertension. Therefore, individuals with high blood pressure exhibit distinct microbial signatures, with a greater abundance of pathogenic bacteria like Prevotella, Klebsiella, and Streptococcus, alongside a reduction in beneficial, SCFA-producing bacteria like Bacteroidetes, Roseburia, and Faecalibacterium. Previous studies showed that animal models of hypertension demonstrated less diverse and rich gut microbiota compared to normotensive controls, suggesting a causal role for gut dysbiosis in blood pressure regulation.

Keywords: Gut microbiota dysbiosis, Hypertension, Angiotensin II, Gut microbiome