Submitted: 11 Jan 2021
Accepted: 15 Apr 2021
ePublished: 05 Jun 2021
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J Ren Endocrinol. 2021;7: e15.
doi: 10.34172/jre.2021.15
  Abstract View: 1155
  PDF Download: 675

Original Article

The relation between vitamin D status and anemia in patients with end stage renal disease on regular hemodialysis

Essam Nour el Din Afifi 1, Ahmed Mohamed Tawfik 1, Essam Eldin Rashed Saeed Abdulkhalek 2, Lina Essam Khedr 1* ORCID logo

1 Department of Internal Medicine and Nephrology, Ain Shams University, Cairo, Egypt.
2 Cairo University, Cairo, Egypt.
*Corresponding Author: Email: linakhedr@med.asu.edu.eg


Introduction: Anemia is a common complication in end-stage renal disease (ESRD) patients on regular hemodialysis (HD). There has been a lot of interest recently in the non-classical effects of 25(OH) vitamin D (calcidiol), including its association with erythropoiesis and anemia pathogenesis.

Objectives: To study the relation between anemia and vitamin D status in patients on regular HD.

Patient and Methods: This study is a cross-sectional study that included 90 patients on regular HD. Vitamin D status was classified into deficient (<20 ng/mL), insufficient (20-30 ng/mL) and sufficient (>30 ng/mL).
Results: The level of vitamin D measured in the patients ranged between 3.5 to 66 ng/mL with median of 16.35 ng/mL. There were statistically significant positive correlations between vitamin D levels and the level of hemoglobin (P<0.001), serum calcium levels (P<0.001) and serum PO4 levels (P=0.023). Higher hemoglobin levels were statistically related to both higher vitamin D values (P<0.001) and higher serum calcium concentration (P<0.001). Meanwhile, a significant negative correlation was found between hemoglobin levels and serum PTH values (P<0.001).

Conclusion: There was a significant association between the status of vitamin D and the level of hemoglobin in dialysis population who were studied, independent from iron status. other associations with hemoglobin levels included PTH level and calcium.

Citation: Nour el Din Afifi E, Tawfik AM, Abdulkhalek EERS, Essam Khedr L. The relation between vitamin D status and anemia in patients with end stage renal disease on regular hemodialysis. J Renal Endocrinol. 2021;7:e15. doi: 10.34172/jre.2021.15.
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