Nickan Research Institute Journal of Renal Endocrinology 2423-6438 10 1 2024 01 01 Obesity-induced diabetic kidney disease-review on pathophysiology and clinical manifestations e25073 e25073 10.34172/jre.2024.25073 EN Harini Ravi https://orcid.org/0000-0001-5640-3675 Soumik Das https://orcid.org/0000-0003-2106-6562 Ramprasad Elumalai https://orcid.org/0000-0003-2399-1698 Gnanasambandan Ramanathan https://orcid.org/0000-0002-4361-6679 Journal Article 10.34172/jre.2024.25073 2023 02 13 2023 03 09 Obesity is a leading global disease and a major risk factor for diabetes which in turn causes metabolic diseases like chronic kidney disease (CKD) with increased mortality and morbidity. However, the relationship between obesity and diabetic kidney diseases (DKDs) remains unclear. Numerous factors in obesity lead to insulin resistance through adipocyte dysfunction. Insulin resistance is a major player in developing diabetes and promoting kidney disease. Major inflammatory cytokines and adipokines produced by adipocytes in the obese phase have various metabolic effects on the system leading to metabolic diseases. Even though obesity, diabetes, and kidney disease have a well-known correlation, the progression of DKD induced by obesity remains still unclear. In this review, we tried to understand the major pathophysiological mechanism linking obesity and DKDs. In addition, we also try to discuss the clinical manifestations and various effective therapeutics for future treatment.