Nickan Research Institute Journal of Renal Endocrinology 2423-6438 9 1 2023 01 01 Renal endocrine aspects of exercise-induced acute kidney injury (gym nephropathy) e25128 e25128 10.34172/jre.2023.25128 EN Mohammad Reza Moonesan https://orcid.org/0000-0003-4351-0732 Journal Article 10.34172/jre.2023.25128 2023 05 23 2023 07 14 The important renal endocrine aspect implicated in gym nephropathy is the activation of the renin-angiotensin-aldosterone system (RAAS). Intense exercise can lead to increased sympathetic nervous system activity, resulting in the release of renin from the juxtaglomerular cells in the kidneys. Renin acts on angiotensinogen, leading to the generation of angiotensin II, a potent vasoconstrictor. Angiotensin II stimulates the secretion of aldosterone from the adrenal glands, which promotes sodium reabsorption and potassium excretion in the kidneys. The persistent activation of the RAAS in gym nephropathy may contribute to renal damage by causing vasoconstriction and promoting renal inflammation.