Nickan Research Institute Journal of Renal Endocrinology 2423-6438 10 1 2024 01 01 Ameliorating impact of berberine on gut microbiota in chronic kidney disease e25135 e25135 10.34172/jre.2024.25135 EN Sadaf Farnam Nia https://orcid.org/0009-0004-4112-3063 Hamid Nasri https://orcid.org/0000-0003-1673-5741 Simin Mazaheri Tehrani https://orcid.org/0009-0000-5670-0506 Shiva Rouzbahani https://orcid.org/0000-0003-3083-3161 LETTER 10.34172/jre.2024.25135 2023 09 28 2024 01 01 Chronic kidney disease is a global health concern, with a growing frequency, significant economic burden, and raised morbidity and mortality. In this disease, alterations in the gut microbiome’s integrity led to renal failure’s progression. Berberine is a natural substance that balances the efficacy of gut microbiota, which could be beneficial in chronic kidney disease.