Nickan Research Institute Journal of Renal Endocrinology 2423-6438 10 1 2024 01 01 Breast cancer in individuals with type 2 diabetes; a mini-review to the recent concepts e25154 e25154 10.34172/jre.2024.25154 EN Rezvan Ebrahimi https://orcid.org/0009-0007-8507-2984 Sanam Saeifar https://orcid.org/0000-0001-5750-7070 Yasaman Vahdani https://orcid.org/0009-0002-3844-2333 Nahid Moradi https://orcid.org/0000-0001-8629-5257 Journal Article 10.34172/jre.2024.25154 2024 04 18 2024 05 22 Introduction: Pieces of evidence indicate a relationship between breast cancer and type 2 diabetes (T2D) which is a potential risk factor for breast cancer development and progression. Hyperinsulinemia, insulin resistance, chronic inflammation, inflammatory cytokines, and hormonal factors are possible explanations for this association. T2D may also affect the breast cancer treatment course. Neoplastic cells are more chemo-resistant, and chemotherapy adverse effects are more prominent in patients with diabetes and breast cancer at the same time. Diabetic nephropathy is one of the T2D complications that should be considered prior to choosing a therapeutic protocol for breast cancer patients. Hence, collaboration between oncologists, endocrinologists, and nephrologists is essential to provide comprehensive care for T2D and breast cancer patients.