Nickan Research Institute Journal of Renal Endocrinology 2423-6438 11 1 2025 01 01 Aggravation of hypertension by gut microbiota dysbiosis; a short-review on new concepts e25185 e25185 10.34172/jre.2025.25185 EN Hossein Mardanparvar https://orcid.org/0000-0001-7455-5373 Journal Article 10.34172/jre.2025.25185 2024 10 24 2025 02 10 Gut microbiota dysbiosis, characterized by reduced diversity and richness, as well as an imbalance in specific bacterial taxa, is closely associated with hypertension. Therefore, individuals with high blood pressure exhibit distinct microbial signatures, with a greater abundance of pathogenic bacteria like Prevotella, Klebsiella, and Streptococcus, alongside a reduction in beneficial, SCFA-producing bacteria like Bacteroidetes, Roseburia, and Faecalibacterium. Previous studies showed that animal models of hypertension demonstrated less diverse and rich gut microbiota compared to normotensive controls, suggesting a causal role for gut dysbiosis in blood pressure regulation.